Cannabinoids are a chemical component found in cannabis as well as being produced by the human body. Endocannabinoids maintain energy homeostasis, which is essential for maintaining other functions like digestion and mood. The pleasurable and psychoactive effects of THC are attributable to cannabinoid chemicals that function similarly to our endocannabinoids.
Phytocannabinoids are plant-derived chemicals that interact with our bodies' receptors to produce various psychotropic and therapeutic effects, while plants or animals manufacture cannabinoids. Delta-nine, THC, and cannabidiol (CBD) are examples of phytocannabinoids, which are any cannabinoids produced in the trichomes of a cannabis plant that may be extracted from the plant and consumed. Phytocannabinoids have numerous psychotropic and healing properties when ingested.
Phytocannabinoids are present in cannabis resin glands, while cannabinoids may be found in marijuana plants and manufactured by organic chemistry. Phytocannabinoid molecules contain carbon.
Cannabinoid And Its Origin
Cannabis is a herbal drug derived from the Cannabis plant. Cannabinoids are chemicals in Marijuana. The highest amounts of cannabinoids exist in the leaves and blooms of the plant. These are the components of the plant that go into making your medications. More than 130 cannabinoid compounds, such as cannabidiol (CBD), make cannabis feel "high."
What is Cannabidiol?
Cannabidiol is an organically occurring compound found in the hemp plant. While CBD oil and medicine are made from cannabis, it doesn't create a "high" effect as recreational marijuana use does. Cannabidiol contains less than 0.03% of THC (Tetrahydrocannabinol), which is the element that gives marijuana users their euphoric high feeling when they smoke or ingest weed.
What Are the Categories of Cannabinoids?
There are three categories of cannabinoids such as:
- Endogenous Phytocannabinoids
- Synthetic Phytocannabinoids.
Phyto-Cannabidiols (or Phytocannabinoids)
The most basic phytocannabinoid definition is any cannabinoid produced in the glandular trichomes of a cannabis plant. Phytocannabinoids interact with our body's receptors to create various psychoactive and therapeutic actions when ingested from the plant. Both plants and animals generate cannabinoids.
Phytocannabinoids are found primarily in plants in the Cannabis family. The following is a list of phytocannabinoids found in plants in the Cannabis family.
You may find other forms of phytocannabinoids in plants;
We specialize in garden and tree care. The term "Phyto" is defined as "pertaining to" or derived from plants.
Phytocannabinoids are natural chemical messengers found to interact with the ELS by binding to a cannabinoid receptor that's found in that system.
A type of cannabinoid made by decarboxylating an appropriate acid, Phytocannabinoids are high in the resin that distills the cannabis plant.
Phytocannabinoids are insoluble in water but soluble in alcohol & fat—among other solvents. When alkanes are added, they form the water-soluble salt called phenolate. This cannabis resin is made up of Terpenes that can produce cannabis' characteristic smell. You can find cannabis in resin-rich plants.
Endocannabinoids are cannabinoids manufactured in the body that function similarly to phytocannabinoids, and they bind to CB receptor sites with ease. They activate or improve our endocannabinoid system (ECS) capabilities without creating intoxicating effects like THC.
Endocannabinoids are substances made by the human body that imitate natural cannabinoids such as:
Cannabinoids help to bind receptors in the endocannabinoid system to make a network of cell surface receptors. Cannabinoid receptors include:
Our central nervous system contains CB1 receptors. These can include receptors that can also be found in all species of mammals. These receptors may be activated by phytocannabinoids, which are natural chemicals that bind to these sites.
CB1 is expressed on presynaptic terminals of primary afferent fibers, where CB2 expression is upon immune cells.
Marijuana and THC stimulate the CB1 receptor, the main mode of action for their psychoactive and euphoric effects. The CB1 receptor is also activated by endogenous cannabinoids released in response to brain damage and other illnesses.
Immune cells primarily express the CB2 receptors. It regulates the release of inflammatory cytokines and the migration of immune cells from the blood into the brain.
CB 1 and CB 2 receptors have been discovered in the brain and other peripheral tissues, including the liver, skeletal muscle, heart, gut, bones, and adipose tissue ( 9 – 13 ).
Endocannabinoid system (ECS) mediators include AEA and MAGL that are broken down by two enzymes:
➢ Fatty acid amide hydrolase (FAAH)
➢ Monoacylglycerol lipase (MAGL)
Several fatty acid-derived mediators present, such as N -palmitoyl-, N -oleoyl-ethanolamine (PEA), 2-oleoyl-, 2-linoleoyl-glycerol (2-OG), and-arachidonoyl glyceryl ether.
Synthetic cannabinoids are the most common cannabinoids consumed for recreational purposes. Synthetic cannabinoids are artificial chemicals that emulate the effects of THC and CBD but with often unknown toxicity profiles.
They come in dried leaves that can be smoked or made into a liquid to use in vaporizers. Herbal incense consists mostly of synthetic cannabinoids with therapeutic potential.
New psychoactive substances have been around for a while. They are made to imitate the effects of other illicit drugs but often have very different effects. NPS are synthetic substances that can be abused and produce the same effects as illegal drugs.
What Are The Classes of Cannabinoids?
There are 113 distinct cannabinoids, 66 of which have been identified. The least two most common cannabinoids are THC and CBD.
➢ THC - TCH is a psychoactive compound that can grant the user "high" symptoms.
➢ CBD - CBD is one of 85 non-psychoactive cannabinoids that have been shown to have many medicinal benefits.
Cannabinoids are becoming increasingly popular in the medical industry, with the most well-known being Δ9-THC. It is known for its psychoactive properties that give people that euphoric high.
The second well-known cannabinoid is cannabidiol (CBD), quickly rising in popularity as a compound with huge health benefits. You can apply it to treating anxiety and depression in humans, whereas cats have shown improved quality of life after just a few weeks.
There are multiple cannabinoids, amongst them:
Exogenous Cannabinoids, Endocannabinoids Vs. Phytocannabinoids
What makes the difference between phytocannabinoids and endocannabinoids?
What's the difference between endocannabinoids and phytocannabinoids?
What are Phytocannabinoids?
Phytocannabinoids are cannabinoids derived from plants such as Cannabis Sativa, also known as Marijuana. At least 85 different chemical compounds belong to a class of molecules called cannabinoids produced by all vertebrates.
Phytoncides, terpenes, and cannabinoids are present in both plants and animals. It is a very potent cannabinoid that contains THC, CBD that gives its user no feeling of euphoria.
CBD does not produce the "high" sensation in the same manner that THC does. When CBD is combined with THC, it's typically accompanied by a feeling of intoxication. All products containing high amounts of CBD would need to include Marijuana and not cannabis. As a result, all CBD items should come from hemp plants instead of cannabis plants and the hemp oil used to make CBD oils. The practice of utilizing CBD for pets is necessary to ensure sanitary and clean living spaces."
Endocannabinoid deficiency means a dietary deficiency of Phytocannabinoids. It is believed that Phytocannabinoid supplementation would help the human body alleviate all kinds of diseases and illnesses, including cancer, autism, fibromyalgia, chronic pain, etc.
The EndoCannabinoid (ECB) System consists of two receptors called CB-R & EC-R. These cannabinoid receptor sites are present in almost all animals on earth. The ECB or endocannabinoid system ECS regulates homeostasis for our bodies. Many different functions like sleep cycle, balancing moods and regulating inflammation are necessary to keep us healthy and alive.
When CBD enters your body, it attaches itself to both cannabinoid receptor sites, which you can find throughout the brain nervous system.
Deficiency of endocannabinoids may occur due to several reasons, such as when:
Everyone these days is talking about the medicinal benefits of CBD, such as its healthy inflammatory response. Some people find the idea that CBD can offer many health benefits to our body a bit of a mind-blower.
This cannabis extract can be derived from either the cannabis or hemp plant. Both hemp and Marijuana are part of the Cannabaceae species. Still, hemp is generally characterized by plants that are low (less than 0.3%) in delta-9 THC, the dominant psychoactive compound in the plant.
Hemp's been used as a plant for many different purposes, from fiber to essential oil and seeds. Hemp is a versatile crop that has been planted for many purposes in the past. Fibers from hemp stalks were once used to construct clothing, paint, and fuel. However, the passage of the Marijuana Tax Act in 1937 rendered the cultivation of hemp illegal in the US.
Is THC a Cannabinoid?
Phytocannabinoids are a type of plant-derived cannabinoid that doesn't exist in the human body. Cannabis consists of many granules that cover your plant's surface. These granules produce their active ingredients. The most well-known and prevalently found cannabinoids, THC & CBD, alleviate anxiety-like symptoms and come with anticarcinogenic properties.
THC is a fatty acid that is the main psychoactive component in cannabis. It activates CB1 receptors, resulting in a high. THC is the psychotropic cannabinoid that makes you high and credits medicinal benefits to THC, but it's crucial to remember that cannabis contains a range of prescription medicines.
THC has been found to increase blood flow to the prefrontal cortex, which is vital for many cognitive processes. How THC affects these functions will differ from person to person. The sense of euphoria that THC cannabinoids induce when they bind to CB1 receptors in the brain is referred to as a "high."
9-THC is a key psychoactive element of Cannabis sativa. The body can trigger many different issues such as:
➢ Psychological problem
➢ Regulation of stomach
➢ Liver and heart function
➢ Pain perception
➢ Changes in the titers or release of brain chemicals called neurotransmitters.
In contrast to this well-known orexigenic effect, many studies have also shown a potential anti-obesity effect of these phytocannabinoid derivatives.
What Is CBD?
CBD is what one would call cannabidiol, a compound found in the cannabis plant with significant medical benefits. CBD is an acronym for Cannabinoid (Cannabinoids are Phytochemicals), and you may have heard of THC, another popular cannabinoid with psychotropic effects like Marijuana.
CBD is a non-psychoactive phytocannabinoid, unlike THC with endocannabinoid effects. The pharmacological chemistry in CBD is still not fully understood. Interest in cannabis medical benefits has steadily increased in the last decade despite not having a specific target in humans. Naturally produced CBD is a key component in the synthesis of new cannabinoids. Here, let's focus on synthesizing chemical derivatives of CBD that can provide an overview of some concerning procedures for studying future synthetic CBD derivatives. There are currently clinical studies underway that confirm the effectiveness of CBD in treating epileptic disorders, schizophrenia, and neurodegenerative diseases. CBD can also treat inflammation.
Is CBD A Cannabinoid?
CBD is the second-most-abundant cannabinoid found in cannabis. Non-intoxicant CBD products are still psychoactive. They provide a soothing effect mostly, rather than feeling "high." An increasing body of evidence suggests that CBD may help with anxiety, chronic pain, and seizures.
The other major cannabinoids include CBN, THCA, and CBDA. CBN stands for CBN-Cannabinol, which is the degraded form of the well-known molecule THC. Older plants can sometimes give off THCA, which is a non-psychoactive cannabinoid. Decarboxylating turns THCA into THC. More broadly, CBD is created from the decarboxylation of CBDA. So far, over 100 other cannabinoids have been isolated from the cannabis plant, though most research has focused on CBD.
Phytocannabinoids: Biosynthetic Pathway
Out of 113 phytocannabinoid substances, the plant C. Sativa contains around 43. The cannabinoids that synthesize similarly include THC and CBD. They come from cannabigerol acid, which is a precursor to cannabis plants.
These cannabinoids, especially THCA, secrete within glandular trichome secretory space. In addition to cannabinoids, the marijuana plant also contains other substances such as terpenes and phenolic compounds. Low-to mid-strength cannabis is recommended for treating seizures. The Avidekel plants have been grown. The amount of cannabinol found in them is 163.3%, while the other compounds are at a low content level.
Is Phytocannabinoid a CBD?
Cannabidiol (CBD) and thyroxine (THC) are a type of phytocannabinoid. Essentially, the human body produces its type of cannabinoids. They are called endocannabinoids. Endocannabinoids are vital to our daily life, helping us to function optimally.
In Massachusetts, medical marijuana expert Jordan Tishler explains the endocannabinoid system and how it could benefit human health. Dr. Tasman also found Marijuana beneficial to humans with promoting Citizen growth.
Phyto is directly related to plants or plant-based. Though most cannabis compounds are found in the cannabis and hemp plant, other plants like liverwort and echinacea contain minor amounts. To date, scientists have identified and found over 100 cannabinoids in the cannabis and hemp plant. It seems like a good idea to use these substances as a treatment for various health conditions. The flowers and the plant's leaves contain cannabinoids, but it's the sticky buds at its top called trichomes that offer a much higher concentration of these compounds. The phytocannabinoids found in the plant are acidic in form.
The Entourage And Ensemble Effect
Cannabinoids are unique to cannabis, but other plant-derived molecules such as flavonoids and terpenes bind to our cells and influence our experiences. Terpenes are a crucial element of the cannabis puzzle as they can contribute to the potential therapeutic benefits of cannabinoids such as THC and CBD.
This potentiated connection between a compound of cannabis is known as the entourage effect. Raphael Mechoulam, an Israeli physician in 2013, said, "The entourage effect has more potential and is stronger than isolated compounds. Recent research has shown that phytocannabinoids work by inducing an aggregation effect.
Other Phytocannabinoids Outside The Cannabis Plant
When referring to cannabis plants, cannabinoids are found within the plant. However, when comparing this term with phytocannabinoids, they are also found in other plants. Indeed, research has yet to find an equally potent phytocannabinoid or cannabinoid that's as strong as THC, but there are similar compounds in different plants.
What Foods Contain Cannabinoids?
Cacao is rich in a mood-regulating chemical called Anandamide. After you eat some, you may notice that your mood improves and energy levels increase. Researchers in Italy recently discovered that black truffles are rich in the neurotransmitter anandamide, activated by kava, a drink originating from the Pacific Islands. Kava is most often used for its natural qualities, which provide relief from anxiety and pain. Helichrysum and other "flower oils" and plants contain compounds that interact with cannabinoid receptors.
What Do Cannabinoids Do To The Body?
Cannabinoids can affect the body in many different ways depending on the cannabinoid receptors being activated. Cutting-over research reveals more and more benefits of cannabinoids, which you can use both medicinally and recreationally. Everybody's function needs a specific balance of things to work at their best. Once the body reaches this state of balance, it's called homeostasis. Cannabinoids and receptors work together to keep your body under homeostasis.
How Do People Use Synthetic Cannabinoids?
The most simple way to use synthetic cannabinoids is to smoke the dried plant material. Users also mix the sprayed plant material with Marijuana or brew it as tea. Other users buy synthetic cannabinoid products as liquids to vaporize in e-cigarettes.
The Benefits of Phytocannabinoids Like THC
There are over 100 phytocannabinoids found in Marijuana, and we're getting a better understanding of how to use them in different ways to treat various diseases. According to studies, "phytocannabinoids" like THC can effectively control pain, insomnia, nausea and vomiting, anxiety and depression, etc.
New insights are leading to more targeted treatments. For example, THC-A may be helpful to those who have autoimmune diseases such as Rheumatoid Arthritis and Lupus. CBD has been focused on because it does not have psychedelic effects, but THC-A does not produce a "high," which could also benefit them. THC-A is 10-20 times more efficacious as an anti-inflammatory & analgesic than CBD. THC-A is safer than CBD, interacting with many common medications, including blood thinners like Warfarin or Plavix.
➢ CBN (Cannabinol),
Those mentioned above are other exciting components of cannabis that are slowly coming to the fore in the treatment of certain illnesses.
Phytocannabinoids may help improve our overall endocannabinoid tone, potentially helping our bodies achieve and maintain homeostasis once more.
Some people even say that we need cannabinoids like we need other regular nutritional support in our bodies. It is because they provide a critical and solid foundation in maintaining our good health.
Phytocannabinoids: Useful Drugs For The Treatment Of Cancer
An excessive amount of Triacylglycerols (TAGs) in diet can elicit the appearance of adipocyte hyperplasia and subsequent accumulation of lipids in the peripheral organ. CBD is considered a potential therapeutic agent due to its anti-inflammatory and antioxidant, and possible anti-obesity effects. We are particularly highlighting. There are various pharmacological effects of CBD on obesity and fat in various tissue types. In that regard, we also emphasize pharmacological issues.
Phytocannabinoids Promote Calmness & Relaxation
250 mg daily phytocannabinoids have been found to ease stress and decrease anxiety. The ECS has a potent role in the regulated control and maintenance of all body systems. Phytocannabinoids support the ECS essential for regulating body systems following the research on stress and anxiety. In medical studies, 25mg of 25 mg daily has been shown to calm the stress and reduce stress-inducing anxiety.
Phytocannabinoids Help Reduce Inflammation & Pain
Recent studies show that the consumption of fatty fruits and vegetables is associated with inflammation. Much exercise at the gym can aggravate irritability and cause chronic pain. Red and processed meat and food can also cause inflammation.
THC intoxication may cause more blood flow in the prefrontal cortex. The brain can control decision-making, attention, and motor functions, among other key executive functions. When THC binds to the CB1 receptor of the brain's reward system, then symptoms become more intense. THC's ability to relieve pain is because of its interaction with the receptor within the midbrain. The changes may vary depending on a person's usage of THC. If THC is combined with other stimuli-receptors, then the brain might undergo different chemical reactions. THC is a psychoactive drug that affects the body's central nervous system. It contains chemical substances that can cause intoxication.
Molecular Targets Of CBD
CBD may affect inflammatory and neurodegenerative brain cells of the animals and vascular tissues. Various studies show CBD is not toxic, nor does it affect it. CBD has been shown to stimulate synaptic plasticity and facilitate neurogenesis which may explain the positive effect upon the inhibition of psychotic, anxiety aversion behaviors, and depressive behaviors. The mechanisms behind these effects involve multiple cellular targets that increase BDNF levels, suppress microglial activation, and lower proinflammatory mediators. CBD's low binding affinity to cannabinoids, CB1 and CB2, may explain its molecular targets, including cannabinoids and Non-cannabinoids.
However, there are more than 85 different cannabinoids present.
What Is The Endocannabinoid System?
The ECS contains two large cannabinoid receptors (CB1 and CD2 ) situated throughout the mammalian brain and central and peripheral nervous systems. Manipulating endocannabinoid degrading enzymes have shown promise in managing various processes associated with neurodegenerative diseases, cancer, epilepsy, and traumatic brain injuries.
The ECS can significantly influence neuroplasticity, neuroinflammation, and cerebrovascular breakdown. It is also associated with stroke and other trauma. The early 1990 discovery of specific membrane receptors for X9 THC led to an endogenous signaling complex.
Significant biological system like the endocannabinoid system helps in regulating several essential functions of infauna. It includes sleep, memory, ache modulation, digestion, and mood. Even those who never had cannabis have endocannabinoid systems. Humans are not the only unique species who contains endocannabinoid systems. Most animals like invertebrates possess endocannabinoid systems. For example, jellyfish!
Endogenous lipids are the Endocannabinoids, which means that these are extracted from fats.They are produced and synthesized according to the demand of our bodies. It also binds the similar cannabinoid receptors that CBD and TCH react with while using or consuming medical cannabis.
The most abundantly produced endocannabinoids in the body of humans are:
➢ (2-AG) 2-arachidonoylglycerol.
These cannabinoids play an important role in several biological processes. Evidence suggests that Anandamide may be responsible for producing the feeling of euphoria after vigorous exercise, also known as a "runner's high."
The three main components of the ECS include:
➢ Cannabinoid Receptors
➢ Metabolic Enzymes or cannabinoid antagonist
➢ Endogenous cannabinoids
Endocannabinoids are cannabinoids that are produced in the body. Cannabinoid receptors can be divided into two categories:
Anandamide and 2-Arachidonoylglycerol, the two most well-known endocannabinoids, bind to CB1 and CB2 receptors. CB receptors are present all over the body and are responsible for different functions. They also activate several other receptor proteins that are sensitive to heat (TRPV).
2-Arachidonyl glyceryl ether is a lesser-known endogenous cannabinoid that binds to both CB1 and CB2 receptors. Studies have shown that it alleviates eye pressure in rabbits. NADA is a cannabinoid that interacts with CB1 receptors and TRPV1 proteins to produce a physical response, with possible therapeutic applications. It also has antioxidant & neuroprotective properties. Virodhamine binds, or O-arachidonoyl-ethanolamine (OAE) binds to CB2 receptors and has successfully lowered body temperature in mice when administered.
Cannabinoid receptors and Endocannabinoids and phytocannabinoids are present on all of our bodies, particularly with our receptors like CB1 and CB2. These are our two significant cannabinoid receptors. CB1 receptors are mostly found in the healthy powerhouse (brain) of a man, whereas CB2 receptors are abundantly found outside of the central nervous system than concentrated elsewhere. It is mainly found in the immune system.
Cannabinoid Antagonists and Metabolic Enzymes
The endocannabinoid system consists of three parts. The first two are endocannabinoids themselves - chemicals that the body produces to activate cannabinoid receptors in the brain. The third part, which is still being studied, includes enzymes that create and degrade these endocannabinoids. When the ECS is properly functioning then, endocannabinoids are synthesized according to the needs of the body. Unlike neurotransmitters or hormones, it is stored after its synthesis for later use; once endocannabinoids are produced, then they are quickly used and broken down. The enzyme FAAH breaks down Anandamide, and MAGL breaks down the cannabinoid 2-AG. These enzymes can be found in the lungs and break down phytocannabinoids like THC and CBD. It means the high you feel after smoking cannabis lasts longer than when exercising.
Cannabinoids affect a wide range of processes throughout the body, including pain, stress, hunger, energy metabolism, cardiac function, motivation and reward, reproduction, sleep. Cannabinoids have anti-inflammatory and nausea-comforting effects, among other things.
ECS As A Potent Biological System
The endocannabinoid system helps to ensure the proper functioning of the systems within our bodies to regulate and maintain homeostasis( internal equilibrium) or the state in which they can function optimally. Optimal endocannabinoid function is important for your health. When someone's endocannabinoid system isn't working well, it could hurt their wellness. There is some speculation about the deficiency of endocannabinoids. A major contributing factor to a syndrome called CECD. Many people experience it because of miscommunications in the endocannabinoid system. It results in insufficient production of endocannabinoids. Endocannabinoid deficiency syndrome may be associated with fibromyalgia and irritable bowel syndrome (IBS) which is a poorly understood disease.
Effects on the nervous system
Cannabinoids can trigger responses in the human central nervous system, largely due to an interaction with specific receptors. There are CB2 receptors on immune system cells in the brain, but scientists don't completely understand what roles they're playing and their effects. Cannabinoids, which are already produced by our body, are found in the cannabis plant. They provide therapeutic purposes that you can use for various purposes. The nervous system is the major place that THC binds to the CB1 receptors, which are then reactivated to allow specific brain functions.
CB1 receptors are the most popular protein among their kind in the brain. They regulate the release of other important neurotransmitters, such as serotonin, dopamine, and glutamate. Pain relief is an important part of the effects of cannabis, but some people are interested in the CB1 receptors for their euphoric effects.
Although they aren't as prominent throughout the nervous system as CB1, CB2 receptors can be found in some brain parts. They're involved in pain relief, controlling inflammation levels, and preserving the structure of nerve cells. But they're mostly found on immune cells, which can be found circulating throughout your body and brain via the bloodstreamCB2 receptors are found throughout the body and sometimes show up in diseased tissues. They may damage skin, bones, liver, lungs, & cardiovascular system and cause certain digestive disorders. The effect of cannabis on many disorders remains unclear.
You can find therapeutic benefits from both CB1 and CB2 receptors - for example, and both receptors exist in the skin, where cannabinoids can potentially intervene to treat a wide variety of skin conditions. One major difference between CBD and THC is that the latter has a stronger influence on CB1 receptors in the brain, which leads to intoxication. In contrast, CBD only influences CB2 receptors and does not induce change in behavior or mental state. CBD has at least 14 variant mechanisms of action, but it doesn't exactly interact with the endocannabinoid system in quite a similar way that THC does. It is why CBD can initiate therapeutic effects without psychoactive outcomes.
Cannabis research has been expanding for some time now, and more medical applications are being discovered. It's important to note that every human has a unique endocannabinoid system. Our bodies react differently to phytocannabinoids. Evidence suggests that the endocannabinoid system exists, and the effects of cannabinoids on cannabinoid receptors have therapeutic benefits. But cannabis is a complex plant, and there is not enough scientific evidence on its effects to conclude anything yet. Pre-research into the effects of cannabis compounds has shown that different combinations of cannabinoids produce very different feelings.
What Is Phytocannabinoid-Rich Hemp?
Phytocannabinoid-rich hemp has been found to have a great impact on:
➢ The endocannabinoid system.
➢ In promoting calmness and relaxation
➢ To decrease stress and anxiety
➢ To promote a sense of focus and clarity.
Cannabinoids are diverse chemical compounds that interact with cannabinoid receptors on cells that repress neurotransmitter release in the brain.
The dosage of cannabinoids varies from person to person that you might need or get benefit from. It may depend on several factors, including body weight, metabolism, chemistry, and the type of symptom relief you seek.
Because there isn't a one-size-fits-all dosage, it's very important to work out your ideal dosage by initiating with the low dose and then gradually working your way up till you get the desired effects.
Keeping a record over this time can be very useful in helping you remember what dose you've taken, as well as any changes in how you feel.